Erectile dysfunction can wreak havoc in a man’s sexual life by weakening his erections or by making him incapable of having any erections at all.
This condition has many different causes such as heart diseases, neurological diseases, and even habits such as smoking, and excessive drinking. Obesity and an extremely sedentary life can also cause erectile dysfunction.
Contrary to the beliefs that erectile dysfunction is a modern illness, erectile dysfunction has been found in men since ancient times and almost all ancient civilizations mention some quirky cure for it.
But we have been blessed with various scientific researches done in this area over many years and now we have a much more detailed idea about erectile dysfunction, its causes as well as its treatment.
Now we treat erectile dysfunction based on the cause of the treatment, while some kinds of erectile dysfunctions are reversible, some are not, but there is a suitable option for all.
Usually, erectile dysfunction is caused due to psychological issues, and obesity and lifestyle choices such as smoking can be reversed if they follow their treatment properly.
Erectile dysfunction associated with heart diseases, diabetes, and old age are not often reversible, but there are treatments that leave men with irreversible erectile dysfunction to enjoy a healthy sexual life.
There are oral drugs, testosterone injection, penile pumps, surgery, and implants that can be prescribed to men suffering from erectile dysfunction following a thorough examination of their condition.
Among all these treatments, the first one to be prescribed is the use of oral drugs for temporary treatment of erectile dysfunction.
The oral drugs that have been prescribed to men for their treatment across the whole world are Sildenafil, Tadalafil, Avanafil, and Vardenafil.
These are PDE5 inhibiting drugs, which implies that they restrict the action of the PDE5 enzyme in the body of men who suffer from this condition.
Each of the PDE5 inhibiting drugs has different onset periods, as well as the hours of their active state, vary, but they all share the same working mechanism for treating erectile dysfunction.
The working Mechanism of the PDE5 inhibiting drugs for the treatment of erectile dysfunction in Men:
When a man suffering comes in close proximity with his partner or if his senses are aroused in some other way, and he desires physical intimacy, the brain sends a signal to the penile region to begin the production of nitric oxide.
The nitric oxide acts as a vasodilator for our blood vessels, and a rush of blood flows towards the penis making it erect and hard, which is termed as an erection. It indicates that the man is ready to have an intimate sexual connection with his partner.
But if the man is suffering from erectile dysfunction, then the PDE5 enzyme present in their body will inhibit the production of nitric oxide. Without enough nitric oxide to dilate the blood vessels, an adequate amount of blood does not reach the penis to bring out healthy erections.
But if the man has taken any PDE5 inhibiting drug and if it is active in his body at the time of his arousal, then the drug will inhibit the PDE5 enzyme from restricting the production of nitric oxide. With an adequate amount of nitric oxide, the blood flows towards the penis just as it should, and the man has erections.
The most important thing to remember about the working mechanism of all the PDE5 inhibiting drugs is that they must be active in the body to work, and they will only work in the presence of sexual stimulation.
Which PDE5 inhibiting Drug Proves to be Most Effective in the treatment of Erectile Dysfunction?
We have seen that the working mechanism of all the PDE5 inhibiting drugs such as Sildenafil, Avanafil, Vardenafil, and Tadalafil, so they are all equally effective in treating the condition and successfully bringing about erections in men.
Sildenafil being the first prescribed PDE5 inhibiting drug, it has immense popularity in the whole world, both its brand name Viagra and generic brand Cenforce are widely used for the treatment of erectile dysfunction.
This drug takes about 30-60 minutes for its onset, and stay active for hours, the drugs Avanafil and Vardenafil take some 15-30 minutes to get ready and stay active for 5-6 hours.
Tadalafil takes the same 15-30 minutes as its onset time, but it stays active for almost 36 hours, and unlike the others, the lower doses of Tadalafil can be used as a daily medication, so it is preferred by men who have a more active sexual life.
Some people chose other PDE5 inhibiting drugs over Sildenafil citrate as they have much lesser onset duration but there is Kamagra Oral Jelly that is Sildenafil in the edible jelly form, and it takes less than 15 minutes to become active.
Thus we can say that all the PDE5 inhibiting drugs are equally effective, but your doctor may prescribe you the one that he or she thinks is best for your condition. As oral pills of erectile dysfunction are often prescribed to be used when a man requires to have an intimate relationship with his partner, the convenience in taking the pills also is a factor that comes into consideration while choosing them.
There are many misconceptions regarding the oral PDE5 inhibiting drugs that are prescribed for the treatment of erectile dysfunction, one of them is that these drugs increase sexual drive and arouses a man sexually. But that is not true, we have already walked through the working mechanism of the PDE5 inhibiting drugs and we can see that they only restrict the PDE5 enzyme and they have no effect on a man’s sexual drive or arousal.
Another misunderstanding that many people have is that these drugs prevent a man from contracting sexually transmitted diseases, but it is nothing more than a baseless wishful thing. These drugs neither cure nor prevent a man from contracting sexually transmitted diseases so make sure that you use proper means of protection, practice safe coitus, and avoid having intimate physical relationships with strangers.